Milan Rosen (I) Co-Authors Award-Winning Pathology Abstract

Each year, pathologists from all over North America convene to share innovative research in the world of diagnostics at the Annual Meeting for the United States and Canadian Academy of Pathology (USCAP). This year’s meeting took place in National Harbor, Maryland, in March. Practicing pathologists, PhD candidates, and graduate students shared more than 3,000 abstracts and posters, representing some of the most cutting-edge research in the field. Milan Rosen, Class I, was the youngest individual to co-author one of these abstracts. His project, which he completed with two MIT PhD candidates, won an award from the Renal Pathology Society at the USCAP Meeting.

In the hopes of making tissue analysis more accurate and efficient, MIT PhD candidates Lucas Cahill and Tadayuki Yoshitake built a two-photon microscope, which uses a short pulse laser to examine tissue specimen from multiple subsurface depths. Current diagnostic technology requires tissue sectioning—the slicing of blocks of tissue into thin sections—so that pathologists can examine the specimen with a traditional microscope. Nonlinear microscopy (NLM) with the two-photon microscope would allow pathologists to examine an entire block of tissue—called a paraffin block—at one time. This would eliminate the need for meticulous sectioning, making the process more efficient. Milan joined Lucas and Tadayuki to perform comparative data analysis using NLM and traditional tissue examination; his research has shown that NLM may facilitate more accurate quantitative analysis than traditional histology.

Milan, who also co-authored a paper on this topic, hopes to continue work with Lucas and Tadayuki on future nonlinear imaging projects and looks forward to studying biology or chemistry in college.